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Article

Structural and functional insights into human tRNA guanine transgylcosylase.

RNA biology - 15 Oct 2021

Sievers Katharina, Welp Luisa, Urlaub Henning, Ficner Ralf

Abstract excerpt

The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr. While both subunits of the functional heterodimer have been crystallized individually, much of our understanding of its dimer interface or recognition of a target RNA has been inferred from its more thoroughly studied bacterial homolog. However,...

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Identifiers

PMID: 34241577
DOI: 10.1080/15476286.2021.1950980
PMCID: PMC8677009

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