Article
Expression and glycosylation studies of human FGF receptor 4.
Protein expression and purification - 1 Mar 2001
Tuominen H, Heikinheimo P, Loo B M, Kataja K, Oker-Blom C, Uutela M, Jalkanen M, Goldman A
Abstract excerpt
Fibroblast growth factor receptor subtype 4 (FGFR4) has been shown to have special activation properties and just one splicing form, unlike the other FGFRs. FGFR4 overexpression is correlated with breast cancer and therefore FGFR4 is a target for drug design. Our aim is to overexpress high amounts of homogeneous FGFR4 extracellular domain (FGFR4(ed)) for structural studies. We show that baculovirus-insect...
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