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Article

Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum.

Nature - 14 Jun 1990

Buonocore L, Rose J K

Abstract excerpt

The envelope glycoprotein (gp120/41) of the human immunodeficiency virus (HIV-1) attaches the virus to the cellular CD4 receptor and mediates virus entry into the cytoplasm. In addition to being required for formation of infectious HIV, expression of gp120/41 at the plasma membrane causes the cytopathic fusion of cells carrying the CD4 antigen. The expression of gp120/41 is therefore an ideal target for...

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Identifiers

PMID: 2190096
DOI: 10.1038/345625a0

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum.PMID 2190096Read ↗

Functional analysis of the disulfide-bonded loop/chain reversal region of human immunodeficiency virus type 1 gp41 reveals a critical role in gp120-gp41 association.Semantic proximity Read ↗

The Transmembrane Domain of HIV-1 gp41 Inhibits T-Cell Activation by Targeting Multiple T-Cell Receptor Complex Components through Its GxxxG Motif.Semantic proximity Read ↗

Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41.Semantic proximity Read ↗

Analysis of endoproteolytic cleavage and intracellular transport of human immunodeficiency virus type 1 envelope glycoproteins using mutant CD4 molecules bearing the transmembrane endoplasmic reticulum retention signal.Semantic proximity Read ↗

Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma.Semantic proximity Read ↗

Mutations in the cytoplasmic domain of human immunodeficiency virus type 1 transmembrane protein impair the incorporation of Env proteins into mature virionsSemantic proximity Read ↗

Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptidesSemantic proximity Read ↗

Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusionSemantic proximity Read ↗

A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity.Semantic proximity Read ↗

Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins.Semantic proximity Read ↗

Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release.Semantic proximity Read ↗

Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding.Semantic proximity Read ↗

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