Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum.

doi:10.1038/345625a0

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Article

Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum.

Nature - 14 Jun 1990

Buonocore L, Rose J K

Abstract excerpt

The envelope glycoprotein (gp120/41) of the human immunodeficiency virus (HIV-1) attaches the virus to the cellular CD4 receptor and mediates virus entry into the cytoplasm. In addition to being required for formation of infectious HIV, expression of gp120/41 at the plasma membrane causes the cyt...

Topics

Amino Acid Sequence
Base Sequence
Biological Transport
CD4 Antigens
Cloning, Molecular
Endoplasmic Reticulum
Fluorescent Antibody Technique
Gene Expression
Genetic Therapy
HIV Envelope Protein gp120
HIV Envelope Protein gp41
HIV-1
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Oligosaccharides

Source

Open in PubMed

Identifiers

PMID: 2190096
DOI: 10.1038/345625a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2190096-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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