Article
Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis.
BMC cancer - 4 Dec 2010
Hutter Carolyn M, Slattery Martha L, Duggan David J, Muehling Jill, Curtin Karen, Hsu Li, Beresford Shirley A A, Rajkovic Aleksandar, Sarto Gloria E, Marshall James R, Hammad Nazik, Wallace Robert, Makar Karen W, Prentice Ross L, Caan Bette J, Potter John D, Peters Ulrike
Abstract excerpt
BACKGROUND: Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility. METHODS: We examined 11 SNP markers in the 8q24 region between 128.47 and 128.54 Mb, using a total of 1,987 colon cases and 2,339 controls who self-reported as white from two independent,...
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