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Article

Cumulative evidence for relationships between multiple variants in 8q24 and colorectal cancer incidence.

Medicine - 1 Aug 2018

Tong Yu, Wang Huiqing, Li Shiping, Zhao Fengyan, Ying Junjie, Qu Yi, Mu Dezhi

Abstract excerpt

Genome-wide association studies (GWAS) have identified multiple independent cancer susceptibility loci at chromosome 8q24.We conducted a comprehensive research synopsis and meta-analysis to evaluate associations between 6 variants in 8q24 and risk of colorectal cancer using data from 31 eligible articles totaling 41,942 cases and 49,968 controls.Of the 6 variants located in 8q24, 3 were significantly associated...

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Chromosomes, Human, Pair 8
Colorectal Neoplasms
Genetic Variation
Genome-Wide Association Study
Heterozygote

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PMID: 30170403
DOI: 10.1097/MD.0000000000011990
PMCID: PMC6392673

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