Article
Characterization of 9p24 risk locus and colorectal adenoma and cancer: gene-environment interaction and meta-analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2010
Kocarnik Jonathan D, Hutter Carolyn M, Slattery Martha L, Berndt Sonja I, Hsu Li, Duggan David J, Muehling Jill, Caan Bette J, Beresford Shirley A A, Rajkovic Aleksandar, Sarto Gloria E, Marshall James R, Hammad Nazik, Wallace Robert B, Makar Karen W, Prentice Ross L, Potter John D, Hayes Richard B, Peters Ulrike
Abstract excerpt
BACKGROUND: A potential susceptibility locus for colorectal cancer on chromosome 9p24 (rs719725) was initially identified through a genome-wide association study, though replication attempts have been inconclusive. METHODS: We genotyped this locus and explored interactions with known risk factors as potential sources of heterogeneity, which may explain the previously inconsistent replication. We included...
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