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Article

Phenotypic variations in glioma stem cells: regulatory mechanisms and implications for therapeutic strategies.

Journal of translational medicine - 2 Sept 2025

Tian Guofeng, Song Yifu, Zhang Yaochuan, Kan Liang, Hou Ana, Han Sheng

Abstract excerpt

Glioma represents the most prevalent primary tumors of the central nervous system, originating from glial cells. Cancer stem cells have the ability to extensively proliferate, self-renew, and form colonies, which contribute to tumorigenesis. Studies have found a population of cells within glioblastoma exhibiting characteristics similar to those of cancer cells, termed glioma stem cells (GSCs). GSCs have two...

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Identifiers

PMID: 40898306
DOI: 10.1186/s12967-025-07034-9
PMCID: PMC12403308

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