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Article

CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells.

Cell reports - 15 Aug 2017

Johansson Elinn, Grassi Elisa S, Pantazopoulou Vasiliki, Tong Bei, Lindgren David, Berg Tracy J, Pietras Elin J, Axelson Håkan, Pietras Alexander

Abstract excerpt

Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. Still, little is known about differential HIF regulation in stem versus bulk glioma cells. We show that the intracellular domain of stem cell marker CD44 (CD44ICD) is released at hypoxia, binds HIF-2α (but not HIF-1α), enhances HIF target gene activation, and is...

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PMID: 28813675
DOI: 10.1016/j.celrep.2017.07.049

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