Article
A novel single nucleotide polymorphisms detection sensors based on magnetic nanoparticles array and dual-color single base extension.
Journal of nanoscience and nanotechnology - 1 Aug 2010
Liu Hongna, Li Song, Tian Lan, Liu Lishang, He Nongyue
Abstract excerpt
To fulfill the increasing need for large-scale genetic research, a high-throughput and automated SNPs genotyping method based on gold coated magnetic nanoparticles (GMNPs) array and dual-color single base extension has been designed. Biotinylated single base extension primer were captured onto the GMNPs coated with streptavidin. Dual-color fluorescence single base extension was employed as a tool for SNPs...
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