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Article

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies.

PloS one - 15 Nov 2010

Weyrich Peter, Staiger Harald, Stančáková Alena, Machicao Fausto, Machann Jürgen, Schick Fritz, Stefan Norbert, Kuusisto Johanna, Laakso Markku, Schäfer Silke, Fritsche Andreas, Häring Hans-Ulrich

Abstract excerpt

BACKGROUND: Toll-like-receptor 4 (TLR) is discussed to provide a molecular link between obesity, inflammation and insulin resistance. Genetic studies with replications in non-diabetic individuals in regard to their fat distribution or insulin resistance according to their carrier status of a common toll-like receptor 4 (TLR4) variant (TLR4(D299G/T399I)) are still lacking. METHODOLOGY/PRINCIPAL FINDINGS: We...

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Identifiers

PMID: 21125016
DOI: 10.1371/journal.pone.0013980
PMCID: PMC2981584

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies.PMID 21125016Read ↗

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