Back to search

Article

A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen <i>Candida albicans</i>

2019-05-08

Abstract excerpt

Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. This suppleness requires an effective mechanism to reprogram reversibly the primary metabolism in response to oxygen variation. Here, we have uncovered that Snf5, a subunit of S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bc7361ee-d5ca-51a5-a2ab-708acec613fd
DOI
10.1101/631960
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen <i>Candida albicans</i>DOI 10.1101/631960
Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicansSemantic proximity
Transcriptional control of hypoxic hyphal growth in the fungal pathogen <i>Candida albicans</i>Semantic proximity
The Snf1‐activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicansSemantic proximity
Mitochondrial complex I bridges a connection between regulation of carbon flexibility and gastrointestinal commensalism in the human fungal pathogen Candida albicansSemantic proximity
Crosstalk between the Ino80 complex and TOR signaling drives fungal adaptation to hypoxia through chromatin remodelingSemantic proximity
<i>Candida auris</i> Metabolism and Growth Preferences in Physiologically Relevant Skin-like ConditionsSemantic proximity
Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophagesSemantic proximity
Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in <i>Candida albicans</i>Semantic proximity
A PAS Protein Directs Metabolic Reprogramming during Cryptococcal Adaptation to HypoxiaSemantic proximity
The <i>ATO</i> gene family governs <i>Candida albicans</i> colonisation in the dysbiotic gastrointestinal tractSemantic proximity
The SAGA and NuA4 component Tra1 regulates <i>Candida albicans</i> drug resistance and pathogenesisSemantic proximity
<i>QCR7</i> affects the virulence of <i>Candida albicans</i> and the uptake of multiple carbon sources present in different host nichesSemantic proximity
Select a neighboring publication to make it the new centre.