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Article

The transcription factor Flo8 mediates CO<sub>2</sub>sensing in the human fungal pathogen<i>Candida albicans</i>

24 May 2012

Abstract excerpt

Physiological levels of CO(2) have a profound impact on prominent biological attributes of the major fungal pathogen of humans, Candida albicans. Elevated CO(2) induces filamentous growth and promotes white-to-opaque switching. However, the underlying molecular mechanisms of CO(2) sensing in C. albicans are insufficiently understood. Here we identify the transcription factor Flo8 as a key regulator of...

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PMID: 22621896
DOI: 10.1091/mbc.e12-02-0094

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