Article
Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals.
Current opinion in microbiology - 1 Dec 2011
Hogan Deborah A, Muhlschlegel Fritz A
Abstract excerpt
In the healthy individual, Candida albicans is frequently found as a harmless commensal residing in the gastrointestinal tract. However, in the compromised patient, C. albicans may invade the body and cause disease that is associated with poor prognosis and high mortality. The C. albicans adenylyl cyclase, Cyr1, which is required for virulence in animal models, regulates three developmental programs, including...
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