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Article

"Single nucleotide polymorphisms of the OPG/RANKL system genes in primary hyperparathyroidism and their relationship with bone mineral density".

BMC medical genetics - 20 Dec 2011

Piedra María, García-Unzueta María T, Berja Ana, Paule Blanca, Lavín Bernardo A, Valero Carmen, Riancho José A, Amado José A

Abstract excerpt

BACKGROUND: Primary hyperparathyroidism (PHPT) affects mainly cortical bone. It is thought that parathyroid hormone (PTH) indirectly regulates the activity of osteoclasts by means of the osteoprotegerin/ligand of the receptor activator of nuclear factor-κβ (OPG/RANKL) system. Several studies have confirmed that OPG (osteoprotegerin) and RANKL (ligand of the receptor activator of nuclear factor-κβ) loci are...

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Source

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Identifiers

PMID: 22185226
DOI: 10.1186/1471-2350-12-168
PMCID: PMC3267665

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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