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Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice

1 Feb 2022

Abstract excerpt

HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here, we used cryo-electron tomography to analyze Env in mature and immature HIV-1 particles. Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into...

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PMID: 35123651
DOI: 10.1016/j.cell.2022.01.013

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