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Article

Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.

The Biochemical journal - 15 Oct 2005

Ariyanayagam Mark R, Oza Sandra L, Guther Maria Lucia S, Fairlamb Alan H

Abstract excerpt

Trypanothione plays a pivotal role in defence against chemical and oxidant stress, thiol redox homoeostasis, ribonucleotide metabolism and drug resistance in parasitic kinetoplastids. In Trypanosoma brucei, trypanothione is synthesized from glutathione and spermidine by a single enzyme, TryS (trypanothione synthetase), with glutathionylspermidine as an intermediate. To examine the physiological roles of...

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Identifiers

PMID: 16008527
DOI: 10.1042/BJ20050911
PMCID: PMC1276942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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