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Article

Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose.

PloS one - 29 Nov 2010

Wright Ann K, Wishart Thomas M, Ingham Cali A, Gillingwater Thomas H

Abstract excerpt

BACKGROUND: Disruption of synaptic connectivity is a significant early event in many neurodegenerative conditions affecting the aging CNS, including Alzheimer's disease and Parkinson's disease. Therapeutic approaches that protect synapses from degeneration in the aging brain offer the potential to slow or halt the progression of such conditions. A range of animal models expressing the slow Wallerian Degeneration...

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Identifiers

PMID: 21124744
DOI: 10.1371/journal.pone.0015108
PMCID: PMC2993971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose.PMID 21124744Read ↗

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