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Article

The neuroprotective factor Wld(s) fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy.

Neuroscience letters - 16 Jan 2009

Kariya Shingo, Mauricio Rina, Dai Ya, Monani Umrao R

Abstract excerpt

Spinal muscular atrophy (SMA) is a common autosomal recessive neurodegenerative disorder in humans. Amongst the earliest signs of neurodegeneration are severe and progressive defects of the neuromuscular synapse. These defects, characterized by poor terminal arborization and immature motor endpla...

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Identifiers

PMID: 19010394
DOI: 10.1016/j.neulet.2008.10.107
PMCID: PMC2671206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19010394-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The neuroprotective factor Wld(s) fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy.PMID 19010394Read ↗

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Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.Semantic proximity Read ↗

Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron DysfunctionSemantic proximity Read ↗

Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophySemantic proximity Read ↗

Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose.Semantic proximity Read ↗

The spinal muscular atrophy mouse model, SMAΔ7, displays altered axonal transport without global neurofilament alterations.Semantic proximity Read ↗

Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophySemantic proximity Read ↗

The Wld(S) mutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathway in vivo.Semantic proximity Read ↗

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