Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammatory bowel disease: an impaired barrier disease.

Langenbeck's archives of surgery - 1 Jan 2013

Jäger Simon, Stange Eduard F, Wehkamp Jan

Abstract excerpt

BACKGROUND: The intestinal barrier is a delicate structure composed of a single layer of epithelial cells, the mucus, commensal bacteria, immune cells, and antibodies. Furthermore, a wealth of antimicrobial peptides (AMPs) can be found in the mucus and defend the mucosa. Different lines of investigations now point to a prominent pathophysiological role of defensins, an important family of AMPs, in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Paneth Cells
Share to Antimicrobial Cationic Peptides
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Defensins

Share to Immunogenetics

Share to Intestinal Mucosa

Share to Intestine, Small

Share to Nod2 Signaling Adaptor Protein

Source

Identifiers

PMID: 23160753
DOI: 10.1007/s00423-012-1030-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammatory bowel disease: an impaired barrier disease.PMID 23160753Read ↗

Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease—Focusing on Intestinal Barrier FunctionSemantic proximity Read ↗

Defensin-immunology in inflammatory bowel disease.Semantic proximity Read ↗

Ulcerative colitis: Recent advances in the understanding of disease pathogenesisSemantic proximity Read ↗

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease.Semantic proximity Read ↗

Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.Semantic proximity Read ↗

Crohn's Disease Enteritis: Pathophysiological Mechanisms and Therapeutic Approaches.Semantic proximity Read ↗

Inflammatory bowel disease: pathogenesis.Semantic proximity Read ↗

Recent understanding of IBD pathogenesis: implications for future therapies.Semantic proximity Read ↗

[Inflammatory bowel disease: IBD].Semantic proximity Read ↗

New insights into inflammatory bowel disease pathophysiology: paving the way for novel therapeutic targets.Semantic proximity Read ↗

Unravelling the pathogenesis of inflammatory bowel disease.Semantic proximity Read ↗

Making sense of the cause of Crohn’s – a new look at an old diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.