Article
Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.
Arthritis and rheumatism - 1 Dec 2010
Hughes Laura B, Reynolds Richard J, Brown Elizabeth E, Kelley James M, Thomson Brian, Conn Doyt L, Jonas Beth L, Westfall Andrew O, Padilla Miguel A, Callahan Leigh F, Smith Edwin A, Brasington Richard D, Edberg Jeffrey C, Kimberly Robert P, Moreland Larry W, Plenge Robert M, Bridges S Louis
Abstract excerpt
OBJECTIVE: Large-scale genetic association studies have identified >20 rheumatoid arthritis (RA) risk alleles among individuals of European ancestry. The influence of these risk alleles has not been comprehensively studied in African Americans. We therefore sought to examine whether these validated RA risk alleles are associated with RA risk in an African American population. METHODS: Twenty-seven candidate...
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