Genetic studies of rheumatoid arthritis.

doi:10.2183/pjab.91.410

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Article

Genetic studies of rheumatoid arthritis.

Proceedings of the Japan Academy. Series B, Physical and biological sciences - 1 Jan 2015

Yamamoto Kazuhiko, Okada Yukinori, Suzuki Akari, Kochi Yuta

Abstract excerpt

Rheumatoid arthritis (RA) is a common autoimmune disease that results in significant morbidity. As with other complex disorders, genome-wide association studies (GWASs) have greatly contributed to the current understanding of RA etiology. In this review, we describe the genetic configuration of RA as revealed primarily through GWASs and their meta-analyses. In addition, we discuss the pathologic mechanisms of RA...

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