Article
Detecting epistasis with restricted response patterns in pairs of biallelic loci.
Annals of human genetics - 1 Jan 2011
Wirapati Pratyaksha, Forner Karl, Delgado-Vega Angelica, Alarcón-Riquelme Marta, Delorenzi Mauro, Wojcik Jérôme
Abstract excerpt
Well-established examples of genetic epistasis between a pair of loci typically show characteristic patterns of phenotypic distributions in joint genotype tables. However, inferring epistasis given such data is difficult due to the lack of power in commonly used approaches, which decompose the epistatic patterns into main plus interaction effects followed by testing the interaction term. Testing additive-only or...
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