Article
Analyzing High-Order Epistasis from Genotype-Phenotype Maps Using 'Epistasis' Package.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Chen Junyi, Wong Ka-Chun
Abstract excerpt
Epistasis is the phenomenon about the interactions between genes, leading to complex phenotypic effects. The interactions between three or more mutations called "high-order epistasis" aroused significant interests in recent studies. However, there are still debates for analysis of high-order epistasis due to the non-linear model complexity and statistical artifacts. A recent "epistasis" Python package was...
Topics
- Algorithms
- Aspergillus niger
- Datasets as Topic
- Epistasis, Genetic
- Escherichia coli
- Genetic Association Studies
- Genotype
- Humans
- Mutation
- Nonlinear Dynamics
- Phenotype
- Software