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Article

Optimization of high-resolution melting analysis for simultaneous genotyping of two 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms.

Genetic testing and molecular biomarkers - 1 Jan 2000

Dujic Tanja, Ostanek Barbara, Marc Janja, Causevic Adlija, Mlinar Barbara

Abstract excerpt

BACKGROUND: Polymorphisms in HSD11B1, the gene encoding 11β-hydroxysteroid dehydrogenase type 1 enzyme, have been associated with obesity, metabolic syndrome, and type 2 diabetes. In this study, we present an optimized high-resolution melting (HRM) method for genotyping two common polymorphisms of the HSD11B1 gene: rs846910: G>A and rs45487298: insA. METHODS: One hundred DNA samples from patients with polycystic...

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PMID: 21117953
DOI: 10.1089/gtmb.2010.0105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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