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Article

In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor.

Cell - 18 May 1990

Hochstrasser M, Varshavsky A

Abstract excerpt

Metabolic instability is characteristic of regulatory proteins whose in vivo concentrations must vary as a function of time. The cell type-specific alpha 2 repressor of the yeast S. cerevisiae is shown here to have a half-life of only approximately 5 min. Each of the two structural domains of alpha 2 carries a sequence that can independently target a normally long-lived protein for rapid destruction. Moreover,...

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PMID: 2111732
DOI: 10.1016/0092-8674(90)90481-s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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