Article
Alleviation of deleterious effects of protein mutation through inactivation of molecular chaperones.
Molecular genetics and genomics : MGG - 1 Nov 2008
Tomala Katarzyna, Korona Ryszard
Abstract excerpt
Molecular chaperones recognize and bind destabilized proteins. This can be especially important for proteins whose stability is reduced by mutations. We focused our study on a major chaperone system, RAC-Ssb, which assists folding of newly synthesized polypeptides in the yeast cytosol. A sensitive phenotypic assay, the red color of Ade2 mutants, was used to screen for variants with metabolic activity dependent on...
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