Article
Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.
Cell - 24 Jul 1998
Johnson P R, Swanson R, Rakhilina L, Hochstrasser M
Abstract excerpt
Proteolysis by the ubiquitin-proteasome pathway is often regulated, but the mechanisms underlying such regulation remain ill-defined. In Saccharomyces cerevisiae, cell type is controlled by the MAT transcription factors. The alpha2 repressor is a known ubiquitin pathway substrate in alpha haploid...
Topics
- Amino Acid Sequence
- Cysteine Endopeptidases
- Dimerization
- Diploidy
- Fungal Proteins
- Haploidy
- Intramolecular Transferases
- Lipoproteins
- Mating Factor
- Molecular Sequence Data
- Multienzyme Complexes
- Mutation
- Peptides
- Pheromones
- Proteasome Endopeptidase Complex
- Protein Structure, Secondary
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins