Article
Approaches to the study of Rox1 repression of the hypoxic genes in the yeast Saccharomyces cerevisiae.
Methods (San Diego, Calif.) - 1 Mar 1997
Zitomer R S, Limbach M P, Rodriguez-Torres A M, Balasubramanian B, Deckert J, Snow P M
Abstract excerpt
The yeast Saccharomyces cerevisiae is a facultative aerobe that responds to changes in oxygen tension by changing patterns of gene expression. One set of genes that responds to this environmental cue is the hypoxic genes. Oxygen levels are sensed by changes in heme biosynthesis, which controls the transcription of the ROX1 gene, encoding a protein that binds to the regulatory region of each hypoxic gene to...
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