Article
Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization.
The Journal of biological chemistry - 15 Dec 2000
Lenk U, Sommer T
Abstract excerpt
In this study we demonstrate that the Deg1 degradation signal of the transcriptional repressor Matalpha2 confers compartment-specific turnover to a reporter protein. Rapid degradation of a Deg1-containing fusion protein is observed only when the reporter is efficiently imported into the nucleus. In contrast, a reporter that is constantly exported from the nucleus exhibits an extended half-life. Furthermore,...
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