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Article

Homoeo-domain homology in yeast MAT alpha 2 is essential for repressor activity.

Nature - 1 Jan 2000

Porter S D, Smith M

Abstract excerpt

The MAT alpha locus of the yeast Saccharomyces cerevisiae encodes two regulatory proteins, alpha 1 and alpha 2, which are responsible for determining the alpha-cell type. MAT alpha 1 is a positive regulator of alpha-cell-type-specific genes, and MAT alpha 2 is a negative regulator of a-cell-type-specific genes. MAT alpha 2 also determines the a/alpha diploid cell type, in conjunction with the MATa product, a1, by...

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PMID: 3517656
DOI: 10.1038/320766a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Homoeo-domain homology in yeast MAT alpha 2 is essential for repressor activity.PMID 3517656Read ↗

Heterodimerization of the yeast MATa1 and MAT alpha 2 proteins is mediated by two leucine zipper-like coiled-coil motifs.Semantic proximity Read ↗

A possible mechanism for partitioning between homo- and heterodimerization of the yeast homeodomain proteins MATa1 and MATalpha2.Semantic proximity Read ↗

The role of cysteine residues in the homeodomain protein Mat alpha 2 in mating-type control of Saccharomyces cerevisiae.Semantic proximity Read ↗

Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.Semantic proximity Read ↗

The yeast a1 and alpha2 homeodomain proteins do not contribute equally to heterodimeric DNA binding.Semantic proximity Read ↗

AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae.Semantic proximity Read ↗

Engineered improvements in DNA-binding function of the MATa1 homeodomain reveal structural changes involved in combinatorial control.Semantic proximity Read ↗

AAR1/TUP1 protein, with a structure similar to that of the beta subunit of G proteins, is required for a1-alpha 2 and alpha 2 repression in cell type control of Saccharomyces cerevisiae.Semantic proximity Read ↗

The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing.Semantic proximity Read ↗

Interspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts.Semantic proximity Read ↗

Operator-constitutive mutations in a DNA sequence recognized by a yeast homeodomain.Semantic proximity Read ↗

Role of alpha2 protein in donor locus selection during mating type interconversion.Semantic proximity Read ↗

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