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Article

FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling.

European journal of haematology - 1 Mar 2011

Katsumi Akira, Kiyoi Hitoshi, Abe Akihiro, Tanizaki Ryohei, Iwasaki Toshihiro, Kobayashi Miki, Matsushita Tadashi, Kaibuchi Kozo, Senga Takeshi, Kojima Tetsuhito, Kohno Takayuki, Hamaguchi Michinari, Naoe Tomoki

Abstract excerpt

Internal tandem duplication of FMS-like receptor tyrosine kinase 3 (FLT3/ITD) within its juxtamembrane domain is a frequent mutation in adult acute myeloid leukaemia (AML). This mutation causes constitutive activation of FLT3 and is associated with poor prognosis. The high relapse rate of FLT3/IT...

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Source

Identifiers

PMID: 21114537
DOI: 10.1111/j.1600-0609.2010.01556.x

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21114537-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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