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Article

Increased male reproductive success in Ts65Dn "Down syndrome" mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2010

Moore Clara S, Hawkins Charles, Franca Arianna, Lawler Ann, Devenney Benjamin, Das Ishita, Reeves Roger H

Abstract excerpt

The Ts65Dn mouse is trisomic for orthologs of about half the genes on Hsa21. A number of phenotypes in these trisomic mice parallel those in humans with trisomy 21 (Down syndrome), including cognitive deficits due to hippocampal malfunction that are sufficiently similar to human that "therapies" developed in Ts65Dn mice are making their way to human clinical trials. However, the impact of the model is limited by...

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Identifiers

PMID: 21110029
DOI: 10.1007/s00335-010-9300-8
PMCID: PMC3002156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased male reproductive success in Ts65Dn "Down syndrome" mice.PMID 21110029Read ↗

Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome.Semantic proximity Read ↗

Perinatal loss of Ts65Dn Down syndrome mice.Semantic proximity Read ↗

The impact of <i>Mmu</i> 17 non- <i>Hsa</i> 21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the “gold standard” revisitedSemantic proximity Read ↗

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.Semantic proximity Read ↗

Sex-specific developmental phenotypes and their response to neonatal <i>Dyrk1a</i> reduction in the Ts65Dn Down syndrome mouse modelSemantic proximity Read ↗

Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome.Semantic proximity Read ↗

Cognitive and molecular characterization of the Ts66Yah murine model of Down syndrome: deepening on hippocampal changes associated with genotype and agingSemantic proximity Read ↗

Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).Semantic proximity Read ↗

Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.Semantic proximity Read ↗

Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome.Semantic proximity Read ↗

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.Semantic proximity Read ↗

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