Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome.

BioTechniques - 1 Dec 2003

Liu Dong P, Schmidt Cecilia, Billings Timothy, Davisson Muriel T

Abstract excerpt

The Ts65Dn mouse is a segmentally trisomic model for Down syndrome. Until now, Ts65Dn mice have been identified by the laborious methods of either chromosomal analysis of cultured peripheral lymphocytes or fluorescent in situ hybridization (FISH). We report here a quantitative PCR method for genotyping Ts65Dn mice, as well as a phenotypic description for visually preclassifying mice to be genotyped.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Disease Models, Animal
Share to Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genetic Testing

Share to Polymerase Chain Reaction

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 14682051
DOI: 10.2144/03356st02

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome.PMID 14682051Read ↗

Multiplex ligation-dependent probe amplification (MLPA) genotyping assay for mouse models of down syndrome.Semantic proximity Read ↗

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.Semantic proximity Read ↗

Increased male reproductive success in Ts65Dn "Down syndrome" mice.Semantic proximity Read ↗

Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).Semantic proximity Read ↗

Behavioral assessment of the Ts65Dn mouse, a model for down syndrome: Altered behavior in the elevated plus maze and open fieldSemantic proximity Read ↗

Perinatal loss of Ts65Dn Down syndrome mice.Semantic proximity Read ↗

Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome.Semantic proximity Read ↗

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.Semantic proximity Read ↗

Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome.Semantic proximity Read ↗

Characterization of the cardiac phenotype in neonatal Ts65Dn mice.Semantic proximity Read ↗

Lamivudine, a Reverse Transcriptase Inhibitor, Rescues Cognitive Deficits in a Mouse Model of Down SyndromeSemantic proximity Read ↗

Lamivudine, a reverse transcriptase inhibitor, rescues cognitive deficits in a mouse model of down syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.