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Article

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

28 Sept 2007

Abstract excerpt

Children with Down syndrome (DS) display macrocytosis, thrombocytosis, and a 500-fold increased risk of developing megakaryocytic leukemia; however, the specific effects of trisomy 21 on hematopoiesis remain poorly defined. To study this question, we analyzed blood cell development in the Ts65Dn mouse model of DS. Ts65Dn mice are trisomic for 104 orthologs of Hsa21 genes and are the most widely used mouse model...

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Identifiers

PMID: 17901249
DOI: 10.1182/blood-2007-04-085670

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