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Article

Sld2 binds to origin single-stranded DNA and stimulates DNA annealing.

Nucleic acids research - 1 Apr 2011

Kanter Diane M, Kaplan Daniel L

Abstract excerpt

Sld2 is essential for the initiation of DNA replication, but the mechanism underlying its role in replication is not fully understood. The S-phase cyclin dependent kinase (S-CDK) triggers the association of Sld2 with Dpb11, and a phosphomimetic mutation of Sld2, Sld2T84D, functionally mimics the S-CDK phosphorylated state of Sld2. We report that Sld2T84D binds directly to the single-stranded (ss) DNA of two...

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Identifiers

PMID: 21109535
DOI: 10.1093/nar/gkq1222
PMCID: PMC3074145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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