Article
Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes.
BMC genomics - 25 Nov 2010
Nash John He, Villegas Andre, Kropinski Andrew M, Aguilar-Valenzuela Renan, Konczy Paulina, Mascarenhas Mariola, Ziebell Kim, Torres Alfredo G, Karmali Mohamed A, Coombes Brian K
Abstract excerpt
BACKGROUND: Adherent and invasive Escherichia coli (AIEC) are commonly found in ileal lesions of Crohn's Disease (CD) patients, where they adhere to intestinal epithelial cells and invade into and survive in epithelial cells and macrophages, thereby gaining access to a typically restricted host niche. Colonization leads to strong inflammatory responses in the gut suggesting that AIEC could play a role in CD...
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