Article
Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn's disease.
Inflammatory bowel diseases - 1 Jun 2009
Martinez-Medina Margarita, Aldeguer Xavier, Lopez-Siles Mireia, González-Huix Ferran, López-Oliu Carles, Dahbi Ghizlane, Blanco Jesus E, Blanco Jorge, Garcia-Gil L Jesus, Darfeuille-Michaud Arlette
Abstract excerpt
BACKGROUND: Escherichia coli, particularly the adherent-invasive E. coli (AIEC) pathovar, has been increasingly implicated in the ethiopathogenesis of Crohn's disease (CD). We describe the richness, abundance, diversity, and pathogenic features of E. coli and AIEC strains that colonize the intestinal mucosa. METHODS: Approximately 100 E. coli colonies per biopsy from 20 CD patients (18 biopsies from colon and 23...
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