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Article

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

3 Apr 2018

Abstract excerpt

The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1 + MPCs is required for functional β cell generation. We have recently demonstrated the generation of a novel population of human pluripotent stem cell (hPSC)-derived MPCs that exclusively express NKX6.1, independently of PDX1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29615106
DOI: 10.1186/s13287-018-0834-0

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