Article
A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma.
Journal of medical virology - 1 Jan 2011
Liu Shijian, Xie Jiaxin, Yin Jianhua, Zhang Hongwei, Zhang Qi, Pu Rui, Li Chengzhong, Ni Wu, Wang Hongyang, Cao Guangwen
Abstract excerpt
This study aimed to determine hepatitis B virus (HBV) mutations associated independently with the risk of hepatocellular carcinoma (HCC), as adjusted with other mutations in the preS and core promoter regions of HBV genotypes B and C. One hundred and forty HBV-infected patients with HCC and 280 HBV-infected patients without HCC who had intact data of HBV genotyping and DNA sequencing in both regions were involved...
Topics
- Adult
- Carcinoma, Hepatocellular
- Case-Control Studies
- DNA, Viral
- Female
- Genotype
- Hepatitis B Core Antigens
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Male
- Middle Aged