Clinical relevance and public health signifcance of hepatitisB virus genomic variations

doi:10.3748/wjg.15.5761

Article

Clinical relevance and public health signifcance of hepatitisB virus genomic variations

1 Jan 2009

Abstract excerpt

Ten hepatitis B virus (HBV) genotypes (A-J) and 34 HBV subgenotypes have been identified so far. HBV genotypes and subgenotypes have distinct geographical distributions, and have been shown to differ with regard to clinical outcome, prognosis, and response to interferon treatment. Infection with subgenotype A2 is frequently associated with high viral load, resulting in acute infection via horizontal transmission....

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