Article
Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma.
Frontiers of medicine in China - 1 Dec 2010
Xie Jia-Xin, Zhao Jun, Yin Jian-Hua, Zhang Qi, Pu Rui, Lu Wen-Ying, Zhang Hong-Wei, Wang Hong-Yang, Cao Guang-Wen
Abstract excerpt
The association of viral mutations and haplotypic carriages with mutations in the preS region of hepatitis B virus (HBV) genotypes B and C with hepatocellular carcinoma (HCC) is of great significance for the prediction of this malignancy, but it remains obscure. We analyzed the preS sequences of HBV genotypes B and C from 1172 HBV-infected subjects including 231 patients with HCC. As compared with the...
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