Article
Contribution of an adenine to guanine single nucleotide polymorphism of the matrix metalloproteinase-13 (MMP-13) -77 promoter region to the production of anticyclic citrullinated peptide antibodies in patients with HLA-DRB1*shared epitope-negative rheumatoid arthritis.
Modern rheumatology - 1 Jun 2011
Iwamoto Naoki, Kawakami Atsushi, Arima Kazuhiko, Tamai Mami, Nakamura Hideki, Kawashiri Shin-ya, Kita Junko, Okada Akitomo, Koga Tomohiro, Kamachi Makoto, Yamasaki Satoshi, Ichinose Kunihiro, Ida Hiroaki, Origuchi Tomoki, Eguchi Katsumi
Abstract excerpt
We examined whether matrix metalloproteinase-13 (MMP-13) contributes to disease susceptibility or severity of rheumatoid arthritis (RA). Eighty-seven patients with RA whose disease duration was <2 years and 71 healthy controls were enrolled in the study. Adenine (A) to guanine (G) single nucleotide polymorphism (SNP) of the -77 MMP-13 promoter region in RA and healthy controls was determined by polymerase chain...
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