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Article

Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.

Arthritis research & therapy - 1 Jan 2006

Rodriguez-Lopez Julio, Perez-Pampin Eva, Gomez-Reino Juan J, Gonzalez Antonio

Abstract excerpt

Many extracellular matrix (ECM) proteases seem to be important in rheumatoid arthritis (RA) and regulation of their transcription levels is a critical mechanism for controlling their activity. We have investigated, therefore, whether the best-characterized single nucleotide polymorphisms (SNPs) affecting transcription of the ECM proteases that have been related with joint pathology are associated with RA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16356191
DOI: 10.1186/ar1849
PMCID: PMC1526575

Genes

MMP2
PLAT
MMP13
MMP3
MMP7
MMP9

Provenance

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