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Article

Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.

Human molecular genetics - 15 Feb 2011

Mughal Mohamed R, Baharani Akanksha, Chigurupati Srinivasulu, Son Tae Gen, Chen Edmund, Yang Peter, Okun Eitan, Arumugam Thiruma, Chan Sic L, Mattson Mark P

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by expanded polyglutamine repeats in the huntingtin (Htt) protein. Mutant Htt may damage and kill striatal neurons by a mechanism involving reduced production of brain-derived neurotrophic factor (BDNF) and increased oxidative and metabolic stress. Because electroconvulsive shock (ECS) can stimulate the production of BDNF and protect...

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Source

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Identifiers

PMID: 21106706
DOI: 10.1093/hmg/ddq512
PMCID: PMC3024043

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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