Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene therapy in mouse models of huntington disease.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Apr 2011

Southwell Amber L, Patterson Paul H

Abstract excerpt

Huntingtin, the protein that when mutated causes Huntington disease (HD), has many known interactors and participates in diverse cellular functions. Mutant Htt (mHtt) engages in a variety of aberrant interactions that lead to pathological gain of toxic functions as well as loss of normal functions. The broad symptomatology of HD, including diminished voluntary motor control, cognitive decline, and psychiatric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition Disorders
Share to Genetic Therapy
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Mental Disorders

Share to Movement Disorders

Share to Nerve Growth Factors

Share to Neural Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 21489966
DOI: 10.1177/1073858410386236
PMCID: PMC3131092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene therapy in mouse models of huntington disease.PMID 21489966Read ↗

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Semantic proximity Read ↗

Therapeutic Advances for Huntington’s DiseaseSemantic proximity Read ↗

The use of transgenic and knock-in mice to study Huntington's disease.Semantic proximity Read ↗

Delivering a disease-modifying treatment for Huntington's disease.Semantic proximity Read ↗

Molecular Strategies for the Treatment of Huntington's Disease.Semantic proximity Read ↗

A fully humanized transgenic mouse model of Huntington disease.Semantic proximity Read ↗

Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy.Semantic proximity Read ↗

Targeting mutant huntingtin for the development of disease-modifying therapy.Semantic proximity Read ↗

Therapeutics Advancement for Huntington DiseaseSemantic proximity Read ↗

Huntington's disease: progress toward effective disease-modifying treatments and a cure.Semantic proximity Read ↗

An insight into allele-selective approaches to lowering mutant huntingtin protein for Huntington's disease treatment.Semantic proximity Read ↗

Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.