Penalized variance components for association of multiple genes with traits.

doi:10.1002/gepi.22340

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Article

Penalized variance components for association of multiple genes with traits.

Genetic epidemiology - 1 Oct 2020

Schaid Daniel J, Sinnwell Jason P, Larson Nicholas B, Chen Jun

Abstract excerpt

Variance component models have gained popularity for genetic analyses, driven by their flexibility to simultaneously analyze multiple genetic variants in a gene by kernel statistics, and their ability to account for population stratification via genomic relationship matrices. For exploratory analyses with modest sample sizes and a potentially large number of variance components, it can be challenging to use...

Topics

DNA Methylation
Genetic Association Studies
Genetic Variation
Genomics
Humans
Hydrocortisone
Likelihood Functions
Models, Genetic
Phenotype
Stress, Physiological

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Open in PubMed

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PMID: 33463755
DOI: 10.1002/gepi.22340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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