Article
Penalized regression for genome-wide association screening of sequence data.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2011
Zhou H, Alexander D H, Sehl M E, Sinsheimer J S, Sobel E M, Lange K
Abstract excerpt
Whole exome and whole genome sequencing are likely to be potent tools in the study of common diseases and complex traits. Despite this promise, some very difficult issues in data management and statistical analysis must be squarely faced. The number of rare variants identified by sequencing is apt to be much larger than the number of common variants encountered in current association studies. The low frequencies...
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