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Article

Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish.

Scientific reports - 8 May 2018

Wang Xing, Salimi Shabnam, Deng Zhongliang, Perry James, Ryan Kathleen A, Li Zhizhen, Liu Dongfang, Streeten Elizabeth, Shuldiner Alan R, Fu Mao

Abstract excerpt

Wnt1-inducible signaling pathway protein-1 (WISP1) is a novel target of the Wnt pathway for modulating osteogenesis and improving bone strength. However, it is not clear if genetic variants in the WISP1 region are associated with bone mineral density (BMD) in human. The aim of this study is to investigate the role of genetic variation in WISP1 gene as a determinant of BMD in 1,510 Old Order Amish (OOA). We...

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Identifiers

PMID: 29739999
DOI: 10.1038/s41598-018-25272-4
PMCID: PMC5940677

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