Article
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels.
Human genetics - 1 Apr 2007
Coutinho Ana M, Sousa Inês, Martins Madalena, Correia Catarina, Morgadinho Teresa, Bento Celeste, Marques Carla, Ataíde Assunção, Miguel Teresa S, Moore Jason H, Oliveira Guiomar, Vicente Astrid M
Abstract excerpt
Autism is a neurodevelopmental disorder of unclear etiology. The consistent finding of platelet hyperserotonemia in a proportion of patients and its heritability within affected families suggest that genes involved in the serotonin system play a role in this disorder. The role in autism etiology of seven candidate genes in the serotonin metabolic and neurotransmission pathways and mapping to autism linkage...
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