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Article

Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism.

Molecular autism - 1 Jan 2017

Chen Rui, Davis Lea K, Guter Stephen, Wei Qiang, Jacob Suma, Potter Melissa H, Cox Nancy J, Cook Edwin H, Sutcliffe James S, Li Bingshan

Abstract excerpt

BACKGROUND: Autism spectrum disorder (ASD) is one of the most highly heritable neuropsychiatric disorders, but underlying molecular mechanisms are still unresolved due to extreme locus heterogeneity. Leveraging meaningful endophenotypes or biomarkers may be an effective strategy to reduce heterogeneity to identify novel ASD genes. Numerous lines of evidence suggest a link between hyperserotonemia, i.e., elevated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28344757
DOI: 10.1186/s13229-017-0130-3
PMCID: PMC5361831

Genes

USP15
FOXP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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